Understanding Ciprofloxacin Failure in Pseudomonas aeruginosa Biofilm: Persister Cells Survive Matrix Disruption
نویسندگان
چکیده
منابع مشابه
Hyperbaric Oxygen Sensitizes Anoxic Pseudomonas aeruginosa Biofilm to Ciprofloxacin
Chronic Pseudomonas aeruginosa lung infection is characterized by the presence of endobronchial antibiotic-tolerant biofilm, which is subject to strong oxygen (O2) depletion due to the activity of surrounding polymorphonuclear leukocytes. The exact mechanisms affecting the antibiotic susceptibility of biofilms remain unclear, but accumulating evidence suggests that the efficacy of several bacte...
متن کاملBiofilm Matrix and Its Regulation in Pseudomonas aeruginosa
Biofilms are communities of microorganisms embedded in extracellular polymeric substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free-living planktonic counterparts, such as different physiology and high resistance to immune system and antibiotics that render biofilm a source of chronic and persistent infections. A deeper understanding of biofilms will ultim...
متن کاملAssembly and Development of the Pseudomonas aeruginosa Biofilm Matrix
Virtually all cells living in multicellular structures such as tissues and organs are encased in an extracellular matrix. One of the most important features of a biofilm is the extracellular polymeric substance that functions as a matrix, holding bacterial cells together. Yet very little is known about how the matrix forms or how matrix components encase bacteria during biofilm development. Pse...
متن کاملInduced Pseudomonas Aeruginosa Biofilm-Matrix Collapse Fluidizes Cystic Fibrosis Sputum
Cite this article: Baier RE, Meyer AE, Aronica MJ, Merrick JM, Murphy TF, et al. (2016) Induced Pseudomonas Aeruginosa Biofilm-Matrix Collapse Fluidizes Cystic Fibrosis Sputum. JSM Biotechnol Bioeng 3(5): 1066. *Corresponding author Robert E. Baier, Department of Oral Diagnostic Sciences, 3435 Main St. Buffalo, NY 14215 State University of New York at Buffalo, School of Dental Medicine, USA, Te...
متن کاملModeling Pseudomonas aeruginosa biofilm detachment
.................................................................................................................................................................................. 3 Introduction............................................................................................................................................................................ 5 Modeling approach...............
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2019
ISSN: 1664-302X
DOI: 10.3389/fmicb.2019.02603